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   Lead Investigator:    Sandra Barral
   Institution      :    Columbia
   E-Mail           :    smb2174@columbia.edu
   Proposal ID      :    6



   Proposal Description:
   Our aim is to compare the cognitive performance in participants in the Long Life Family Study (LLFS) with age and gender matched unaffected participants in the NACC Study.    Initially, for each of the test including in the neuropsychological battery, we will compare the mean  values between the two groups using Student t-test. Subsequently, to investigate possible interactions  between the different variables, we will also conduct Multiple Linear Regression analysis to  simultaneously modeling all neuropsychological variables.  In both strategies, we will control for potential cofounding factors by including them as covariates in  our analysis such as education, age, gender and center of recruitment.